"Ubiquitin: Proteasome Pathway" ed. by Xianquan Zhan

This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases.

The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases.

Contents
1. Branching and Mixing: New Signals of the Ubiquitin Signaling System
2. Ubiquitin-Independent Proteasomal Degradation Mediated by Antizyme
3. Lys63-Linked Polyubiquitination of Transforming Growth Factor β Type I Receptor (TβRI) Specifies Oncogenic Signaling
4. Ubiquitination and Deubiquitination in Melanoma Research and Clinically Relevant Outcomes
5. New Discoveries on the Roles of “Other” HECT E3 Ubiquitin Ligases in Disease Development
6. Abnormal Ubiquitination of Ubiquitin-Proteasome System in Lung Squamous Cell Carcinomas


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