The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery integrates the experience of diverse experts who offer fundamental and practical guidance across numerous situations.

Mildred Pierce dotes on her daughters while husband Bert looks to Maggie Binderhof for affection. They separate leaving Mildred to raise the girls on her own. Elder daughter Veda goads her mother about their lack of money and in response Mildred proposes opening a small restaurant. Realtor Wally Fay advises her while making numerous rebuffed passes and introduces her to Monte Baragon whose property becomes the first of a chain of restaurants. Mildred has an affair with Monte.

A trio of American crooks board a ship bound for Europe, intending to get rid of $100,000 in stolen dough. With detective John Wade (James Dunn) breathing down their necks, the crooks stash the loot in the trunk belonging to vacationing schoolmarm Mary Smith (Sally Eilers).

'Design by programming' has proved very successful in the development of complex software systems. This book describes the construction of programs for VLSI digital circuit design, using the language Tangram, and shows how they can be compiled automatically in fully asynchronous circuits. Handshake circuits were invented by the author to separate questions involving the efficient implementation of the VLSI circuits from issues arising in their design. Dr van Berkel presents a mathematical theory of handshake circuits and a silicon compiler supported by a correctness proof. The treatment of VLSI realizations of handshake circuits includes various forms of optimization, handshake refinement, message encoding, circuit initialization, and testing. The approach is illustrated with a host of examples drawn from a wide range of application areas. The book will be of use to electrical engineers and computer scientists involved in VLSI design.

Rex Banner, played by Peter Reynolds, is the proprietor of a news agency and having an eye for a good story, becomes an amateur sleuth to find out who murdered his friend Gospel Joe and as a consequence, who was responsible for the theft of the Delavine diamonds sometime earlier. Joe had information about the theft and had asked to see Rex but just as Rex finds his friends body the police arrive and he is initially treated as a suspect.

This comprehensive and succinct encyclopedia traces the origins and development of the Bahá’í Faith from nineteenth-century Iran to the modern day, covering its central figures and major historical events.

While vacationing in Italy, Nick Morell, son of John Morell, a famous English philosopher and amateur musician and his wife Catherine, becomes friendly with young Guido, and Morell discovers the boy has an extraordinary instinct for orchestration and a phenomenal music memory. A neighboring couple, Signor and Signora Boudini become aware of the boy's talents, and she appeals to his parents to let her educate him musically. Torn by their love for their son and, they feel,the duty to let the world hear his talent, they consent.

The champion of uncelebrated foods including fat, offal, and bones, Jennifer McLagan turns her attention to a fascinating, underappreciated, and trending topic: bitterness.

For more than 20 years ChessBase Magazine has been one of the leading international chess journals. The bilingual magazine (English/German) appears every two months and coming as it does as a combined issue of a printed magazine and a DVD it offers the best possible training material for club players and professionals alike.

Luther Heggs aspires to being a reporter for his small town newspaper, the Rachel Courier Express. He gets his big break when the editor asks him to spend the night at the Simmons mansion that, 20 years before, was the site of a now famous murder-suicide. The case has aroused local interest not only because of the anniversary but due to the fact that the family heir, Nick Simmons, has returned to Rachel aiming to tear the mansion down. Luther's account of his wild, ghost-ridden night in the house leads Simmons to sue for libel, but with the aid of his friend Kelsey they determine what exactly happened that night long ago and the identity of the real killer.

The adventures of The Wombles, strange creatures who live on Wimbledon Common and pick up the litter left by the humans. There's always time for a nice song and dance as well. This was a film version of the popular childrens TV show.

Logic is now widely recognized as one of the foundational disciplines of computing and has applications in virtually all aspects of the subject, from software engineering and hardware to programming languages and artificial intelligence. The Handbook of Logic in Artificial Intelligence and its companion The Handbook of Logic in Computer Science were created in response to the growing need for an in-depth survey of these applications. This handbook comprises five volumes, each an in-depth overview of one of the major topics in this area. The result of years of cooperative effort by internationally renowned researchers, it will be the standard reference work in AI for years to come. Volume 5 focuses on logic programming. The chapters, which in many cases are of monograph length and scope, emphasize possible unifying themes.