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Advances in Vision Research, Volume IV

Posted By: AvaxGenius
Advances in Vision Research, Volume IV

Advances in Vision Research, Volume IV: From Basic to Translational Research — Developing Diagnostics and Therapeutics for Genetic Eye Diseases by Gyan Prakash, Takeshi Iwata
English | PDF EPUB (True) | 2024 | 393 Pages | ISBN : 981994435X | 82.7 MB

This fourth volume in the series Advances in Vision Research describes importance advancements in basics to translational research, including new therapeutics for genetic eye diseases. Recent US FDA approval of the first gene therapy for an inherited retinal disease, due to a mutation in the RPE65 gene, has led to an upsurge in translational eye research. The coverage in this volume includes corneal diseases, myopia, cataract, glaucoma, inherited retinal diseases, inherited optic neuropathy, and other genetic eye diseases. New developments such as the application of artificial intelligence in translational eye research are also discussed. All chapters are written by leading researchers working on eye genetics from the fields of Human Genetics, Ophthalmology, Molecular Biology, Biochemistry, Sensory Sciences, and Clinical Research. Advances in Vision Research, Volume IV will be a major resource for all researchers, clinicians, clinical researchers, andallied eye health professionals with an interest in eye diseases around the globe. The first two volumes in the series described the state of the art in genetic eye research in Asia and the Pacific while the third focused on progress in Europe and the United States.

Handbook of Stem Cell Applications

Posted By: AvaxGenius
Handbook of Stem Cell Applications

Handbook of Stem Cell Applications by Khawaja H. Haider
English | PDF EPUB (True) | 2024 | 1422 Pages | ISBN : 9819971187 | 109 MB

This handbook reviews the clinical applications of stem cell-based therapy. The book covers the clinical applications of stem cells in cardiovascular diseases, neurological and ocular diseases, pediatrics, and the role of cancer stem cell-derived exosomal microRNA payload in lung cancer. The chapter reviews emerging stem cell therapy and tissue engineering approaches in neurodegenerative diseases. The book further examines the applications of stem cells in various fields of dentistry, and for the regeneration of oral and non-oral tissues. The chapters also explore the application of 3D bioprinting in conjunction with bone marrow mesenchymal stem cells for the treatment of bone defects and state-of-the-art technology for bone and cartilage regeneration using mesenchymal stem cells. The book presents stem cell-based therapy against renal, pancreatic, and kidney diseases and examines the advantages of a novel hepatic stem for cirrhotic liver repair and regeneration. Lastly, the book provides methodological and procedural advancements in stem cell-based therapy, including the applications of single-cell sequencing in stem cell research. This handbook is a major one-stop reference for researchers working in regenerative medicine, cellular pharmacology, stem cell research in general, and those involved in specific areas of adult stem cells as well as embryonic and induced pluripotent stem cells.

Molecular Basis of Developmental and Stem Cell Regulation: Classical Models Revised

Posted By: AvaxGenius
Molecular Basis of Developmental and Stem Cell Regulation: Classical Models Revised

Molecular Basis of Developmental and Stem Cell Regulation: Classical Models Revised by Hisato Kondoh
English | PDF EPUB (True) | 2024 | 260 Pages | ISBN : 3031390261 | 90.3 MB

This book provides a comprehensive overview of the molecular basis of developmental and stem cell regulation. It revisits some of the classical models of developmental biology and puts them in context with the findings of modern stem cell research and developmental biology.

Bioreactor Systems for Tissue Engineering II: Strategies for the Expansion and Directed Differentiation of Stem Cells

Posted By: AvaxGenius
Bioreactor Systems for Tissue Engineering II: Strategies for the Expansion and Directed Differentiation of Stem Cells

Bioreactor Systems for Tissue Engineering II: Strategies for the Expansion and Directed Differentiation of Stem Cells by Cornelia Kasper, Martijn Griensven, Ralf Pörtner
English | PDF | 2010 | 330 Pages | ISBN : 3642160506 | 5.4 MB

First of all, the editors of this special volume would like to thank all the authors for their excellent contributions. We would also like to thank Prof. Dr. Thomas Scheper as well as Dr.Marion Hertel and Ingrid Samide fromSpringer for providing the opportunity to compose this volume and Springer for organizational and technical support. Tissue engineering represents one of the major emerging fields in modern biotechnology. Tissue engineering combines different disciplines ranging from biological and material sciences to engineering and clinical disciplines. The aim of tissue engineering is the development of therapeutic approaches to substitute diseased organs or tissues or improve their function. Stem cells are early progenitors that may substitute diseased tissues or provide cues for endogenous healing. Stem cells are present in virtually all tissues. The first chapters describe different sources of stem cells including isolation and expansion. The use of fetal tissues and umbilical cord is discussed as they come from immunoprivileged sites and are considered to be early stem cells. The use of adipose-derived stem cells is discussed as a readily available autologous source. Subsequently, newer techniques for “manufacturing” stem cells from somatic cells using “induced pluripotent stem cell” technology are discussed and described in two chapters. The following chapter deals with bioreactor cultivation of stem cells. Specific tissues such as cartilage and endothelial precursors built the bridge to the last chapters.

Applications of Stem Cells and derived Exosomes in Neurodegenerative Disorders

Posted By: AvaxGenius
Applications of Stem Cells and derived Exosomes in Neurodegenerative Disorders

Applications of Stem Cells and derived Exosomes in Neurodegenerative Disorders by Sadaf Jahan, Arif Jamal Siddiqui
English | PDF EPUB (True) | 2023 | 336 Pages | ISBN : 9819938473 | 29.8 MB

This book explores the therapeutic approaches of stem cells and stem cell-derived exosomes against neurodegenerative disorders (NDDs). The initial chapters introduce different neurodegenerative diseases and discuss the mechanistic aspects of their progression. The subsequent chapters cover strategies for the isolation, characterization, and differentiation of stem cells. In turn, the book reviews the protective role of stem cells against neurological disorders and examines regenerative approaches to treat neurological diseases using mesenchymal stem cells. The book also presents induced pluripotent stem cell (iPSC) technology for cellular therapy, drug screening, and in-vitro modeling of neurodegenerative diseases. Lastly, the book discusses the role of stem cells and derived exosomes as a novel therapeutic agent against Alzheimer's and Parkinson's disease and in associated signaling molecules involved in neuroprotection. This book is an invaluable source for researchers working towards understanding the potential of stem cell therapy in neurodegenerative disorders.

Stem Cells

Posted By: AvaxGenius
Stem Cells

Stem Cells by Anna M. Wobus, Kenneth R. Boheler (Investigator)
English | PDF (True) | 2006 | 416 Pages | ISBN : 3540778543 | 4.44 MB

Signi?cant advances in stem cell research and their potentials for therap- tic applications have attracted the attention of the scienti?c community and captured the imagination of society as a whole. Not so long ago, the study of most stem cells, other than those that regenerated the haematopoietic system, was rather obscure and limited to a relatively small number of researchers and laboratories. The uproar over stem cells really began in 1998 with the s- cessful derivation of pluripotent human embryonic stem (ES) cells by James Thomson and co-workers.

"Glioblastoma: Current Evidence" ed. by Amit Agrawal, Daulat Singh Kunwar

Posted By: exLib
"Glioblastoma: Current Evidence" ed. by Amit Agrawal, Daulat Singh Kunwar

"Glioblastoma: Current Evidence" ed. by Amit Agrawal, Daulat Singh Kunwar
ITexLi | 2023 | ISBN: 1803561297 9781803561295 1803561289 9781803561288 1803561300 9781803561301 | 200 pages | PDF | 12 MB

This book discusses glioblastoma (GBM) and its diagnosis, treatment, and management.

"Leukemia: From Biology to Clinic" ed. by Margarita Guenova, Gueorgui Balatzenko

Posted By: exLib
"Leukemia: From Biology to Clinic" ed. by Margarita Guenova, Gueorgui Balatzenko

"Leukemia: From Biology to Clinic" ed. by Margarita Guenova, Gueorgui Balatzenko
ITexLi | 2023 | ISBN: 1803569069 9781803569062 1803569050 9781803569055 1803569077 9781803569079 | 132 pages | PDF | 5 MB

This book does not have the ambition to present comprehensively the problems of leukemias, but it is an attempt to acquaint the audience of specialists involved in clinical management and experimental research with some modern advances and concepts in the three main directions: biology, clinical presentation and treatment.

Computing with Instinct: Rediscovering Artificial Intelligence

Posted By: AvaxGenius
Computing with Instinct: Rediscovering Artificial Intelligence

Computing with Instinct: Rediscovering Artificial Intelligence by Yang Cai
English | PDF | 2011 | 173 Pages | ISBN : 3642197566 | 5.9 MB

Simplicity in nature is the ultimate sophistication. The world's magnificence has been enriched by the inner drive of instincts, the profound drive of our everyday life. Instinct is an inherited behavior that responds to environmental stimuli. Instinctive computing is a computational simulation of biological and cognitive instincts, which influence how we see, feel, appear, think and act. If we want a computer to be genuinely secure, intelligent, and to interact naturally with us, we must give computers the ability to recognize, understand, and even to have primitive instincts.

Epigenetics, Development, Ecology and Evolution

Posted By: AvaxGenius
Epigenetics, Development, Ecology and Evolution

Epigenetics, Development, Ecology and Evolution by Luis María Vaschetto
English | PDF,EPUB | 2022 | 239 Pages | ISBN : 3031137701 | 29.4 MB

Epigenetic modifications comprise heritable gene expression changes that occur without alteration of the DNA sequence and 'co-act' with genetic factors to shape development processes and evolutionary trajectories. Multicellular organisms receive different types of environmental stimuli/stresses that trigger epigenetic modifications during development. These environmentally driven mechanisms represent an underlying cause of phenotypic diversity, especially in metazoans. This book aims to present some of the latest epigenetic insights into the development of metazoans (including humans) as an intersection between their ecology and evolution.

Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory

Posted By: AvaxGenius
Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory

Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory by Aaron R. Friedman
English | PDF | 2013 | 41 Pages | ISBN : 1615044760 | 1.7 MB

Approximately 50 years ago, newly generated neurons were discovered in the adult hippocampus of the rat brain. This discovery contradicted a key principle in mammalian developmental neurobiology—that all the neurons of the brain are made during early development—and led to intensive study to find out how new neurons are generated and how the process of neurogenesis is regulated. Since then, a unique population of adult neural stem cells has been identified, and many of the molecular pathways that control their self-renewal, proliferation, and cell fate have been elucidated. However, the presence of new neurons in the adult brain also poses intriguing functional questions that have, as yet, gone largely unanswered. Why is adult neurogenesis restricted to select brain regions? What functional benefit do these new cells confer? Indeed, the field of adult neurogenesis offers a unique opportunity to study naïve neurons as they mature, form connections with existing neural networks, and begin to participate in information processing. We review the basics of adult NSC biology and the maturation of newborn neurons. In particular, we focus on new neurons in the hippocampus, and how they contribute to function in this key memory-forming structure of the brain.

Plant Breeding in the Omics Era (Repost)

Posted By: AvaxGenius
Plant Breeding in the Omics Era (Repost)

Plant Breeding in the Omics Era by Rodomiro Ortiz Ríos
English | PDF | 2015 | 250 Pages | ISBN : 3319205315 | 2.5 MB

This book provides analysis of plant breeding and its role for producing high-yielding cultivars that increase farming profitability and sustainability. This work analyzes the past and present of plant breeding, while providing research that investigates the future of crop improvement. Plant breeding today, as it was before, depends on crop biodiversity and its sustainable use, which can be further facilitated by advances in omics and bioinformatics. It starts with assessing plant genetic resources (wild species, landraces, obsolete cultivars, genetic stocks) variation aiming to enhance the cultigen pool. Research on genetics–aided by current omic tools– should lead to designing a knowledge-based plant breeding, which could bring further genetic gains in the breeding pools. Plant breeding, however, will increasingly require pursuing a holistic interdisciplinary approach based on integrated system-oriented thinking.

Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols

Posted By: AvaxGenius
Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols

Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols by Kursad Turksen
English | EPUB | 2022 | 426 Pages | ISBN : 1071625845 | 72.8 MB

This detailed volume presents a series of protocols that are representative of recent developments and improvements in induced pluripotent stem cells (iPS cells) and corresponding human disease models. Reflecting the latest technology for generating induced pluripotent stem cells (iPS cells) and their initial characterization, the book explores techniques invaluable both for studies of disease-specific cell types and for their potential applications in regenerative medicine. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls.

Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols

Posted By: AvaxGenius
Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols

Induced Pluripotent Stem Cells and Human Disease: Methods and Protocols by Kursad Turksen
English | PDF | 2022 | 426 Pages | ISBN : 1071625845 | 14.6 MB

This detailed volume presents a series of protocols that are representative of recent developments and improvements in induced pluripotent stem cells (iPS cells) and corresponding human disease models. Reflecting the latest technology for generating induced pluripotent stem cells (iPS cells) and their initial characterization, the book explores techniques invaluable both for studies of disease-specific cell types and for their potential applications in regenerative medicine. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls.

Cell Biology and Translational Medicine, Volume 15: Stem Cells in Tissue Differentiation, Regulation and Disease

Posted By: AvaxGenius
Cell Biology and Translational Medicine, Volume 15: Stem Cells in Tissue Differentiation, Regulation and Disease

Cell Biology and Translational Medicine, Volume 15: Stem Cells in Tissue Differentiation, Regulation and Disease by Kursad Turksen
English | EPUB | 2022 | 209 Pages | ISBN : 3031023773 | 21.2 MB

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.