A modern day look at America's war on drugs told through four separate stories that are connected in one way or another. A conservative judge who's just been appointed as the US drug czar learns that his teenage honor student daughter is a drug addict. A beautiful trophy wife struggles to save her wealthy husband's drug business, while two DEA agents protect a witness with inside knowledge of the spouse's business. In Mexico, a slightly corrupt, yet dedicated cop struggles with his conscience when he learns that his new boss may not be the anti-drug official he made himself out to be.

The battleship Missouri is about to be decomissioned. Casey Ryback is Captain Adam's personal cook. And Ryback is always butting heads with the ship's XO Commander Krill but the Captain always intercedes. One day, after the President visits the Missouri, which is also the Captain's birthday, the Captain learns that a helicopter has been cleared to land on the ship by Commander Krill, which he was not informed of.

John awakens from a coma to discover his wife and daughter were slaughtered in a brutal home invasion. Haunted by images of the attack, he vows to kill the man responsible: Luc Deveraux. While John tries to piece his reality back together, things get more complicated when he is pursued by a relentless UniSol named Magnus. Meanwhile, Deveraux and surviving UniSol Andrew Scott are preparing to battle anarchy and build a new order ruled by Unisols without government oversight.